Publications

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  • † denotes co-first authorship
    ‡ denotes co-corresponding authorship
  • Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application
    Schiffelers LDJ, Tesfamariam YM, Jenster L, Diehl S, Binder SC, Normann S, Mayr J, Pritzl S, Hagelauer E, Kopp A, Alon A, Geyer M, Ploegh HL, Schmidt FI
    Nature Communications
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  • AlphaFold2 structures guide prospective ligand discovery
    Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL
    Science, 2024
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  • The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination
    Gao Y, Barajas-Ornelas RDC, Amon JD, Ramírez-Guadiana FH, Alon A, Brock KP, Marks DS, Kruse AC, Rudner DZ
    Genes Dev, 2022, 36(9-10): 634-646
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  • Structures of the σ2 receptor enable docking for bioactive ligand discovery
    Alon A†, Lyu J†, Braz JM†, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI‡, Shoichet BK‡, Kruse AC‡
    Nature, 2021, 600(7890): 759-764
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  • The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3
    Okalang U, Mualem Bar-Ner B, Rajan KS, Friedman N, Aryal S, Egarmina K, Hope R, Khazanov N, Senderowitz H, Alon A, Fass D, Michaeli S
    mBio, 2021, 12(6): e0260221
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  • Dormant spores sense amino acids through the B subunits of their germination receptors
    Artzi L, Alon A, Brock KP, Green AG, Tam A, Ramírez-Guadiana FH, Marks D, Kruse A, Rudner DZ
    Nat Commun, 2021, 12(1): 6842
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  • Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
    Tummino TA†, Rezelj VV†, Fischer B†, Fischer A†, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, et al.
    Science, 2021, 373(6554): 541-547
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  • COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
    Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Blair RV, Roy CJ, Smith N, Hall JM, Tomera KM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO
    Front Pharmacol, 2021, 12: 633680
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  • cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures
    Javitt G†, Grossman-Haham I†, Alon A, Resnick E, Mutsafi Y, Ilani T, Fass D
    Protein Sci, 2019, 28(1): 228-238
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  • Identification of the gene that codes for the σ2 receptor
    Alon A†, Schmidt HR†, Wood MD†, Sahn JJ, Martin SF, Kruse AC
    Proc Natl Acad Sci U S A, 2017, 114(27): 7160-7165
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  • Structural Perspectives on Sigma-1 Receptor Function
    Alon A, Schmidt H, Zheng S, Kruse AC
    Adv Exp Med Biol, 2017, 964: 5-13
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  • AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences
    Lapidoth GD, Baran D, Pszolla GM, Norn C, Alon A, Tyka MD, Fleishman SJ
    Proteins, 2015, 83(8): 1385-406
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  • An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1
    Grossman I, Alon A, Ilani T, Fass D
    J Mol Biol, 2013, 425(22): 4366-78
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  • A secreted disulfide catalyst controls extracellular matrix composition and function
    Ilani T, Alon A, Grossman I, Horowitz B, Kartvelishvily E, Cohen SR, Fass D
    Science, 2013, 341(6141): 74-6
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  • Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase
    Limor-Waisberg K, Alon A, Mehlman T, Fass D
    FEBS Lett, 2012, 586(23): 4119-25
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  • Exploring ORFan domains in giant viruses: structure of mimivirus sulfhydryl oxidase R596
    Hakim M, Ezerina D, Alon A, Vonshak O, Fass D
    PLoS One, 2012, 7(11): e50649
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  • The dynamic disulphide relay of quiescin sulphydryl oxidase
    Alon A, Grossman I, Gat Y, Kodali VK, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D
    Nature, 2012, 488(7411): 414-8
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  • Improved molecular replacement by density- and energy-guided protein structure optimization
    DiMaio F, Terwilliger TC, Read RJ, Wlodawer A, Oberdorfer G, Wagner U, Valkov E, Alon A, Fass D, Axelrod HL, Das D, Vorobiev SM, Iwaï H, Pokkuluri PR, Baker D
    Nature, 2011, 473(7348): 540-3
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  • QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains
    Alon A, Heckler EJ, Thorpe C, Fass D
    FEBS Lett, 2010, 584(8): 1521-5
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  • Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis
    Heckler EJ, Alon A, Fass D, Thorpe C
    Biochemistry, 2008, 47(17): 4955-63
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